Dementia
Chronic brain syndrome; Lewy body
dementia; DLB; Vascular dementia; Mild cognitive impairment; MCI
Last reviewed: September 26, 2011.
Dementia is a loss of brain function
that occurs with certain diseases. It affects memory, thinking, language,
judgment, and behavior.
See also: Alzheimer's disease
Causes,
incidence, and risk factors
Most types of dementia are
nonreversible (degenerative). Nonreversible means the changes in the brain that
are causing the dementia cannot be stopped or turned back. Alzheimer's disease
is the most common type of dementia.
Lewy body disease is a leading cause
of dementia in elderly adults. People with this condition have abnormal protein
structures in certain areas of the brain.
Dementia also can be due to many
small strokes. This is called vascular dementia.
The following medical conditions
also can lead to dementia:
- Huntington's disease
- Multiple sclerosis
- Infections that can affect the brain, such as HIV /AIDS and Lyme disease
- Parkinson's disease
- Pick's disease
- Progressive supranuclear palsy
Some causes of dementia may be
stopped or reversed if they are found soon enough, including:
- Brain injury
- Brain tumors
- Chronic alcohol abuse
- Changes in blood sugar, sodium, and calcium levels (see: Dementia due to metabolic causes)
- Low vitamin B12 levels
- Normal pressure hydrocephalus
- Use of certain medications, including cimetidine and some cholesterol-lowering medications
Dementia usually occurs in older
age. It is rare in people under age 60. The risk for dementia increases as a
person gets older.
Symptoms
Dementia symptoms include difficulty
with many areas of mental function, including:
- Language
- Memory
- Perception
- Emotional behavior or personality
- Cognitive skills (such as calculation, abstract thinking, or judgment)
Dementia usually first appears as
forgetfulness.
Mild cognitive impairment is the
stage between normal forgetfulness due to aging and the development of
dementia. People with MCI have mild problems with thinking and memory that do
not interfere with everyday activities. They are often aware of the
forgetfulness. Not everyone with MCI develops dementia.
Symptoms of MCI include:
- Difficulty performing more than one task at a time
- Difficulty solving problems or making decisions
- Forgetting recent events or conversations
- Taking longer to perform more difficult mental activities
The early symptoms of dementia can
include:
- Difficulty performing tasks that take some thought, but that used to come easily, such as balancing a checkbook, playing games (such as bridge), and learning new information or routines
- Getting lost on familiar routes
- Language problems, such as trouble finding the name of familiar objects
- Losing interest in things you previously enjoyed, flat mood
- Misplacing items
- Personality changes and loss of social skills, which can lead to inappropriate behaviors
As the dementia becomes worse,
symptoms are more obvious and interfere with the ability to take care of
yourself. The symptoms may include:
- Change in sleep patterns, often waking up at night
- Difficulty doing basic tasks, such as preparing meals, choosing proper clothing, or driving
- Forgetting details about current events
- Forgetting events in your own life history, losing awareness of who you are
- Having hallucinations, arguments, striking out, and violent behavior
- Having delusions, depression, agitation
- More difficulty reading or writing
- Poor judgment and loss of ability to recognize danger
- Using the wrong word, not pronouncing words correctly, speaking in confusing sentences
- Withdrawing from social contact
People with severe dementia can no
longer:
- Perform basic activities of daily living, such as eating, dressing, and bathing
- Recognize family members
- Understand language
Other symptoms that may occur with
dementia:
- Incontinence
- Swallowing problems
Signs
and tests
A skilled health care provider can
often diagnose dementia by performing a physical exam and asking questions
about the person's medical history.
The physical exam will include a
neurological exam. Tests to check mental function will be done. This is called
a mental status examination.
Other tests may be ordered to
determine whether other problems could be causing dementia or making it worse.
These conditions include:
- Anemia
- Brain tumor
- Chronic infection
- Intoxication from medications
- Severe depression
- Thyroid disease
- Vitamin deficiency
The following tests and procedures
may be done:
- B12 level
- Blood ammonia levels
- Blood chemistry (chem-20)
- Blood gas analysis
- Cerebrospinal fluid (CSF) analysis
- Drug or alcohol levels (toxicology screen)
- Electroencephalograph (EEG)
- Head CT
- Mental status test
- MRI of head
- Thyroid function tests
- Thyroid stimulating hormone level
- Urinalysis
Treatment
Treatment depends on the condition
causing the dementia. Some people may need to stay in the hospital for a short
time.
Stopping or changing medications
that make confusion worse may improve brain function.
There is growing evidence that some
kinds of mental exercises can help dementia.
Treating conditions that can lead to
confusion often greatly improve mental functioning. Such conditions include:
- Anemia
- Congestive heart failure
- Decreased blood oxygen (hypoxia)
- Depression
- Heart failure
- Infections
- Nutritional disorders
- Thyroid disorders
Medications may be needed to control
behavior problems caused by a loss of judgment, increased impulsivity, and
confusion. Possible medications include:
- Antipsychotics (haloperidol, risperidone, olanzapine)
- Mood stabilizers (fluoxetine, imipramine, citalopram)
- Stimulants (methylphenidate)
Certain drugs may be used to slow
the rate at which symptoms worsen. The benefit from these drugs is often small,
and patients and their families may not always notice much of a change.
- Donepezil (Aricept), rivastigmine (Exelon), galantamine (Razadyne, formerly called Reminyl)
- Memantine (Namenda)
A person's eyes and ears should be
checked regularly. Hearing aids, glasses, or cataract surgery may be needed.
Psychotherapy or group therapy
usually does not help because it may cause more confusion.
For information on how to take care
of a loved one with dementia, see: Dementia - home care
Expectations
(prognosis)
People with mild cognitive
impairment do not always develop dementia. However, when dementia does occur,
it usually gets worse and often decreases quality of life and lifespan.
Complications
Complications depend on the cause of
the dementia, but may include the following:
- Abuse by an overstressed caregiver
- Increased infections anywhere in the body
- Loss of ability to function or care for self
- Loss of ability to interact
- Reduced lifespan
- Side effects of medications used to treat the disorder
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